Across TCGA cell cohorts, SPRED2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,884 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRED2-associated GO terms across cancer lineages are Negative regulation of lens fiber cell differentiation, Regulation of lens fiber cell differentiation, and Regulation of mononuclear cell proliferation. Each is linked with SPRED2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of lens fiber cell differentiation →	+1.592	+2.437	<.001	<.001	3	18
BLOOD_Myeloma	Regulation of lens fiber cell differentiation →	+1.616	+2.375	<.001	<.001	3	15
KIDNEY	Regulation of mononuclear cell proliferation →	-0.086	-0.869	<.001	<.001	3	9
URINARY_TRACT	Complement activation, lectin pathway →	-1.391	-0.579	.008	.003	3	9
OVARY	Regulation of lymphocyte proliferation →	-0.084	-0.625	.003	.005	3	8
BLOOD_Leukemia	Copper ion export →	-0.171	-0.794	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,884 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types