Across TCGA cell cohorts, SPRED2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SPRED2-associated genes across cancer lineages are UTF1, FDCSP, and IQCF5. Each is linked with SPRED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	FDCSP →	+0.681	+3.453	<.001	.009	3	1
LARGE_INTESTINE	IQCF5 →	+0.025	+4.022	<.001	.006	3	1
BREAST	OOSP2 →	+0.023	+5.781	<.001	.001	3	1
BREAST	OR10J5 →	+0.071	+5.169	<.001	.005	3	1
BREAST	OR10J1 →	+0.566	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types