SPRED1

Across TCGA cell cohorts, SPRED1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,869 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPRED1-associated GO terms across cancer lineages are Regulation of lens fiber cell differentiation, Negative regulation of lens fiber cell differentiation, and Regulation of transforming growth factor beta receptor signaling pathway. Each is linked with SPRED1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPRED1-to-partner and partner-to-SPRED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lens fiber cell differentiation grouped by SPRED1-low versus SPRED1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED1→partner) and Y-score (partner→SPRED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of lens fiber cell differentiation →	+1.327	+1.181	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of lens fiber cell differentiation →	+1.298	+1.269	<.001	<.001	3	15
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.090	+1.652	<.001	<.001	3	13
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.094	+1.571	<.001	<.001	3	13
KIDNEY	Vasculogenesis involved in coronary vascular morphogenesis →	+1.083	+0.921	<.001	.005	3	12
BONE	Negative regulation of transforming growth factor beta receptor signaling pathway →	+0.081	+1.354	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,869 associations by consensus.

Regulation of lens fiber cell differentiation by SPRED1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →