SPRED1

Across TCGA cell cohorts, SPRED1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRED1-associated genes across cancer lineages are C6orf118, GZMK, and OCM2. Each is linked with SPRED1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED1-to-partner and partner-to-SPRED1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SPRED1-low versus SPRED1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED1→partner) and Y-score (partner→SPRED1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.143	+3.115	<.001	.004	3	1
LARGE_INTESTINE	GZMK →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OCM2 →	+0.047	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GLYATL1B →	+0.063	+2.878	.004	.009	3	1
LARGE_INTESTINE	CLEC18C →	+0.140	+3.333	.004	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C6orf118 by SPRED1 expression — LARGE_INTESTINE

Explore this box plot interactively →