SPR

Across TCGA pan-cancer cohorts, SPR Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPR data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SPR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPR expression acts as an unfavorable survival marker.

COAD, STAD, and LUAD are the cancer types where SPR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.309	0.803	<.001	16	view →
STAD	OS	Median	All	0.255	0.688	.045	12	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPR–COAD (OS)

Open the COAD breakdown →