SPPL3

Across TCGA patient cohorts, SPPL3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL3-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and Annexin-1. Each is linked with SPPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPPL3-to-partner and partner-to-SPPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SPPL3-low versus SPPL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL3→partner) and Y-score (partner→SPPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.435	-3.169	.038	.019	3	2
UCEC	PCNA →	+0.345	+2.584	<.001	.011	3	2
UCEC	Annexin-1 →	+0.898	+3.341	<.001	.005	3	2
UCEC	C-Raf →	+0.228	+3.700	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.851	+3.169	.001	.018	3	2
UCEC	eIF4E →	+0.198	+3.000	.044	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p38-MAPK_pT180_Y182 by SPPL3 expression — UCEC

Explore this box plot interactively →