Across TCGA patient cohorts, SPPL2C RNA expression is significantly associated with the protein abundance of many other proteins, with 8,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPPL2C-associated proteins across cancer lineages are CBX1, PSIP1, and MAPT. Each is linked with SPPL2C in more than 3 cancer types. Because this analysis shows association rather than direction, both SPPL2C-to-partner and partner-to-SPPL2C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2C→partner) and Y-score (partner→SPPL2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CBX1 →	+0.362	+0.565	.001	.001	3	4
GBM	PSIP1 →	+0.504	+0.618	.003	.002	3	3
BRCA	MAPT →	+1.141	+0.261	<.001	<.001	3	3
GBM	OSBPL3 →	-0.340	-0.569	.001	.001	3	3
CCRCC	ZEB1 →	+0.372	+0.268	.005	.008	3	3
LUAD	TPPP3 →	+0.847	+0.012	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,126 associations by consensus.

Exploration

SPPL2C survival (RNA) · tumor vs normal (RNA) · all SPPL2C data types