Across TCGA patient cohorts, SPPL2C mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL2C-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Src_pY527, and 4E-BP1_pT37_T46. Each is linked with SPPL2C in more than 2 cancer types. Because this analysis shows association rather than direction, both SPPL2C-to-partner and partner-to-SPPL2C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2C→partner) and Y-score (partner→SPPL2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	p38-MAPK_pT180_Y182 →	-0.405	-2.984	.025	.034	3	3
STAD	Src_pY527 →	-0.565	-3.169	.020	.019	3	2
STAD	4E-BP1_pT37_T46 →	-0.513	-2.978	.007	.033	3	2
COAD	Rab11 →	+0.147	+2.347	.043	.019	3	2
COAD	TSC1 →	-0.411	-3.321	<.001	.009	3	2
COAD	beta-Catenin →	-0.925	-3.450	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

SPPL2C survival (RNA) · tumor vs normal (RNA) · all SPPL2C data types