SPPL2B

Across TCGA patient cohorts, SPPL2B protein abundance is significantly associated with the RNA expression of many other genes, with 7,010 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SPPL2B-associated genes across cancer lineages are PLEKHJ1, TMEM205, and ICOS. Each is linked with SPPL2B in more than 2 cancer types. Because this analysis shows association rather than direction, both SPPL2B-to-partner and partner-to-SPPL2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPPL2B versus PLEKHJ1 in LUAD, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2B→partner) and Y-score (partner→SPPL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PLEKHJ1 →	+0.396	+0.258	<.001	.004	3	3
LUAD	TMEM205 →	+0.484	+0.317	.002	.003	3	3
HNSC	ICOS →	-1.106	-0.695	.001	<.001	3	3
GBM	MED16 →	+0.600	+0.354	<.001	<.001	3	3
UCEC	R3HDM4 →	+0.531	+0.443	.006	.003	3	3
HNSC	RPL32P1 →	-1.158	-0.407	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,010 associations by consensus.

SPPL2B vs PLEKHJ1 — LUAD

Explore this scatter interactively →