SPPL2B

Across TCGA patient cohorts, SPPL2B mutation is significantly associated with the RNA expression of many other genes, with 2,392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL2B-associated genes across cancer lineages are KRT19P6, DTWD1, and BLOC1S6. Each is linked with SPPL2B in more than 2 cancer types. Because this analysis shows association rather than direction, both SPPL2B-to-partner and partner-to-SPPL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT19P6 grouped by SPPL2B-low versus SPPL2B-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2B→partner) and Y-score (partner→SPPL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	KRT19P6 →	+0.100	+5.008	<.001	.002	3	3
UCEC	DTWD1 →	+0.348	+2.831	.002	.001	3	3
UCEC	BLOC1S6 →	+0.562	+2.403	<.001	<.001	3	3
UCEC	GALNT7 →	+0.728	+2.021	.001	.001	3	3
UCEC	KAT2B →	+0.609	+2.032	<.001	.001	3	3
UCEC	BRCA1 →	+0.514	+2.392	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,392 associations by consensus.

KRT19P6 by SPPL2B expression — LUSC

Explore this box plot interactively →