SPPL2B

Across TCGA patient cohorts, SPPL2B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL2B-associated genes across cancer lineages are MEK1, p27, and Chk2_pT68. Each is linked with SPPL2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SPPL2B-to-partner and partner-to-SPPL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SPPL2B-low versus SPPL2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2B→partner) and Y-score (partner→SPPL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.320	+3.807	.026	<.001	3	2
UCEC	p27 →	+0.242	+4.000	.004	<.001	3	2
UCEC	Chk2_pT68 →	-0.146	-2.575	.045	.010	3	2
UCEC	A-Raf_pS299 →	-0.124	-2.584	.007	.010	3	1
UCEC	ERK2 →	+0.173	+2.807	.021	.003	3	1
UCEC	Notch1 →	+0.142	+1.584	.010	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by SPPL2B expression — UCEC

Explore this box plot interactively →