SPPL2B

Across TCGA cell cohorts, SPPL2B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,601 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPPL2B-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Subtelomeric heterochromatin formation, and mRNA splice site recognition. Each is linked with SPPL2B in more than 16 cancer types. Because this analysis shows association rather than direction, both SPPL2B-to-partner and partner-to-SPPL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SPPL2B-low versus SPPL2B-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2B→partner) and Y-score (partner→SPPL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.237	+1.716	<.001	<.001	3	17
LARGE_INTESTINE	Subtelomeric heterochromatin formation →	+0.151	+1.608	<.001	<.001	3	16
OESOPHAGUS	mRNA splice site recognition →	+0.153	+1.449	<.001	.001	3	16
STOMACH	Viral translational termination-reinitiation →	+0.096	+1.149	.005	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.089	+1.650	<.001	<.001	3	16
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.180	+1.475	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,601 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SPPL2B expression — OESOPHAGUS

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