SPPL2A

Across TCGA patient cohorts, SPPL2A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPPL2A-associated genes across cancer lineages are RAD51, STAT3_pY705, and TSC1. Each is linked with SPPL2A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPPL2A-to-partner and partner-to-SPPL2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by SPPL2A-low versus SPPL2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2A→partner) and Y-score (partner→SPPL2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.159	+3.169	.038	.020	3	1
UCEC	STAT3_pY705 →	-0.409	-2.990	.004	.036	3	1
UCEC	TSC1 →	-0.300	-3.169	.001	.020	3	1
UCEC	Bim →	-0.294	-3.169	.041	.020	3	1
UCEC	Rad50 →	-0.263	-3.169	.048	.020	1	1
UCEC	Bcl-2 →	-0.409	-3.143	.032	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RAD51 by SPPL2A expression — UCEC

Explore this box plot interactively →