SPP2

Across TCGA patient cohorts, SPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,679 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPP2-associated GO terms across cancer lineages are Post-translational protein targeting to membrane, translocation, Regulation of carbohydrate metabolic process, and Steroid biosynthetic process. Each is linked with SPP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SPP2-to-partner and partner-to-SPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-translational protein targeting to membrane, translocation grouped by SPP2-low versus SPP2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP2→partner) and Y-score (partner→SPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Post-translational protein targeting to membrane, translocation →	+0.067	+0.083	<.001	<.001	3	7
STAD	Regulation of carbohydrate metabolic process →	+0.051	+0.081	<.001	<.001	3	7
STAD	Steroid biosynthetic process →	+0.046	+0.092	<.001	<.001	3	7
STAD	L-amino acid transport →	+0.041	+0.071	<.001	<.001	3	6
STAD	Positive regulation of lipid biosynthetic process →	+0.045	+0.089	<.001	<.001	3	6
STAD	Nucleus organization →	+0.073	+0.092	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,679 associations by consensus.

Post-translational protein targeting to membrane, translocation by SPP2 expression — STAD

Explore this box plot interactively →