SPP2

Across TCGA patient cohorts, SPP2 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPP2-associated genes across cancer lineages are RN7SL539P, BPY2C, and TMEM138. Each is linked with SPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPP2-to-partner and partner-to-SPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL539P grouped by SPP2-low versus SPP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP2→partner) and Y-score (partner→SPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL539P →	+0.114	+8.471	<.001	.005	3	2
LGG	BPY2C →	+0.019	+7.977	<.001	.007	3	2
UCEC	TMEM138 →	+0.280	+3.483	.004	.002	3	2
UCEC	MRPL17 →	+0.347	+3.191	.006	.009	3	2
UCEC	PHB →	+0.521	+2.321	.006	.006	3	2
UCEC	DAPK3 →	+0.500	+2.354	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

RN7SL539P by SPP2 expression — BRCA

Explore this box plot interactively →