SPP2

Across TCGA patient cohorts, SPP2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPP2-associated genes across cancer lineages are N-Ras, Src, and Di-Ras3. Each is linked with SPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPP2-to-partner and partner-to-SPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Ras grouped by SPP2-low versus SPP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP2→partner) and Y-score (partner→SPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	N-Ras →	-0.252	-3.000	.001	.035	3	2
SKCM	Src →	-0.333	-3.000	.011	.036	3	2
SKCM	Di-Ras3 →	-0.245	-2.987	.002	.035	3	2
UCEC	Rab25 →	-0.432	-2.321	.002	.033	3	2
SKCM	GAPDH →	+0.813	+3.000	.015	.036	3	1
SKCM	STAT5a →	+0.668	+3.000	.035	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

N-Ras by SPP2 expression — SKCM

Explore this box plot interactively →