SPP2

Across TCGA cell cohorts, SPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 323 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SPP2-associated GO terms across cancer lineages are Positive regulation of leukocyte differentiation, Positive regulation of hemopoiesis, and Middle ear morphogenesis. Each is linked with SPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPP2-to-partner and partner-to-SPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of leukocyte differentiation grouped by SPP2-low versus SPP2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP2→partner) and Y-score (partner→SPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of leukocyte differentiation →	+0.046	+0.052	.002	.009	2	4
LUNG_NSCLC_LUAD	Positive regulation of hemopoiesis →	+0.046	+0.052	.002	.009	2	4
BREAST	Middle ear morphogenesis →	-0.847	-0.035	.008	.002	3	3
BREAST	Regulation of T cell differentiation →	+0.056	+0.031	.007	.008	3	3
SKIN	Mitotic spindle assembly →	+0.068	+0.037	.004	.007	3	3
BREAST	Stem cell division →	+0.147	+0.036	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

Positive regulation of leukocyte differentiation by SPP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →