SPP2

Across TCGA cell cohorts, SPP2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPP2-associated genes across cancer lineages are C1QL2, MMP26, and OR10W1. Each is linked with SPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPP2-to-partner and partner-to-SPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by SPP2-low versus SPP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP2→partner) and Y-score (partner→SPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QL2 →	+0.005	+4.099	.002	<.001	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LARGE_INTESTINE	GAGE12H →	+0.055	+4.022	<.001	.006	3	1
LARGE_INTESTINE	IL5 →	+0.169	+3.491	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C1QL2 by SPP2 expression — LARGE_INTESTINE

Explore this box plot interactively →