Across TCGA pan-cancer cohorts, SPOUT1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPOUT1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SPOUT1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPOUT1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where SPOUT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.870	0.548	.001	28	view →
LUAD	DFS	Quartile	All	0.845	0.444	.003	21	view →
CCRCC	DFS	Tertile	III,IV	0.805	1.000	.010	12	view →
UCEC	OS	Quartile	III,IV	0.711	0.250	.040	4	view →
HNSC	OS	Median	All	0.807	0.905	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SPOUT1 tumor-vs-normal RNA expression · all SPOUT1 data types