Across TCGA patient cohorts, SPOUT1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOUT1-associated genes across cancer lineages are EGFR_pY1068, Gab2, and MEK1. Each is linked with SPOUT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOUT1-to-partner and partner-to-SPOUT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOUT1→partner) and Y-score (partner→SPOUT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.319	-2.459	.008	.020	3	1
UCEC	Gab2 →	+0.383	+2.459	.026	.020	3	1
UCEC	MEK1 →	+0.418	+3.584	.017	.002	3	1
UCEC	Notch1 →	+0.147	+3.013	.030	.018	3	1
UCEC	Rad50 →	-0.275	-2.459	.019	.020	3	1
UCEC	Shc_pY317 →	-0.224	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SPOUT1 survival (RNA) · tumor vs normal (RNA) · all SPOUT1 data types