SPOPL

Across TCGA patient cohorts, SPOPL protein abundance is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPOPL-associated genes across cancer lineages are ETV7, EIF3B, and UGDH. Each is linked with SPOPL in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOPL-to-partner and partner-to-SPOPL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPOPL versus ETV7 in BRCA, with a Pearson correlation of -0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOPL→partner) and Y-score (partner→SPOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ETV7 →	-3.003	-0.959	.007	.006	3	1
BRCA	EIF3B →	-0.853	-0.593	.001	.006	3	1
BRCA	UGDH →	+1.803	+0.570	.002	.009	3	1
BRCA	ALG2 →	+1.423	+1.003	.004	.005	3	1
BRCA	ZNF835 →	+0.880	+0.409	.001	.008	3	1
BRCA	DUSP26 →	-0.731	-0.593	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

SPOPL vs ETV7 — BRCA

Explore this scatter interactively →