SPOPL

Across TCGA patient cohorts, SPOPL mutation is significantly associated with the RNA expression of many other genes, with 3,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOPL-associated genes across cancer lineages are MIR4769, CCDC116, and GFI1. Each is linked with SPOPL in more than 2 cancer types. Because this analysis shows association rather than direction, both SPOPL-to-partner and partner-to-SPOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by SPOPL-low versus SPOPL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOPL→partner) and Y-score (partner→SPOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4769 →	+0.236	+4.199	.001	.009	3	3
UCEC	CCDC116 →	+0.174	+1.978	<.001	.002	3	2
UCEC	GFI1 →	+0.304	+2.024	.006	.001	3	2
UCEC	HPGDS →	-0.349	-2.736	<.001	<.001	3	2
UCEC	LRR1 →	+0.517	+2.237	<.001	<.001	3	2
UCEC	SNRPD1 →	+0.360	+2.010	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,170 associations by consensus.

MIR4769 by SPOPL expression — SKCM

Explore this box plot interactively →