SPOPL

Across TCGA patient cohorts, SPOPL mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOPL-associated genes across cancer lineages are C-Raf, eEF2, and EGFR_pY1173. Each is linked with SPOPL in more than 2 cancer types. Because this analysis shows association rather than direction, both SPOPL-to-partner and partner-to-SPOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SPOPL-low versus SPOPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOPL→partner) and Y-score (partner→SPOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.172	+2.662	<.001	<.001	3	3
UCEC	eEF2 →	+0.314	+2.700	.006	.005	3	2
UCEC	EGFR_pY1173 →	+0.051	+1.096	.043	.040	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-1.510	.006	.008	3	2
UCEC	Cyclin-E2 →	+0.188	+2.331	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.292	-2.378	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

C-Raf by SPOPL expression — UCEC

Explore this box plot interactively →