SPOPL

Across TCGA cell cohorts, SPOPL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,879 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPOPL-associated GO terms across cancer lineages are Insulin receptor signaling pathway, Post-Golgi vesicle-mediated transport, and CRD-mediated mRNA stabilization. Each is linked with SPOPL in more than 13 cancer types. Because this analysis shows association rather than direction, both SPOPL-to-partner and partner-to-SPOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Insulin receptor signaling pathway grouped by SPOPL-low versus SPOPL-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOPL→partner) and Y-score (partner→SPOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Insulin receptor signaling pathway →	+0.058	+0.519	<.001	.001	3	14
STOMACH	Post-Golgi vesicle-mediated transport →	+0.075	+0.725	.001	.008	3	13
STOMACH	CRD-mediated mRNA stabilization →	+0.128	+0.687	.001	.005	3	13
LARGE_INTESTINE	Vesicle budding from membrane →	+0.075	+0.741	<.001	<.001	3	11
OVARY	Positive regulation of cytoplasmic translation →	+0.145	+0.640	<.001	<.001	3	11
OVARY	Regulation of translational initiation →	+0.107	+0.824	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,879 associations by consensus.

Insulin receptor signaling pathway by SPOPL expression — CNS

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