SPOP

Across TCGA pan-cancer cohorts, SPOP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPOP data layer compared with 30 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPOP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPOP expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where SPOP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.872	.016	14	view →
PDAC	DFS	Median	All	0.366	0.948	.038	3	view →
GBM	DFS	Quartile	All	0.500	0.205	.027	2	view →
LSCC	OS	Tertile	III,IV	1.000	0.633	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPOP–HNSC (DFS)

Open the HNSC breakdown →