SPOP

Across TCGA pan-cancer cohorts, SPOP mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPOP’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SPOP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SPOP is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where SPOP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPOP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.148	.006	4	view →
LUAD	Female	II,III,IV	−0.270	.005	3	view →
CCRCC	All	III,IV	−0.622	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SPOP–LSCC

Open the LSCC breakdown →