SPOP

Across TCGA patient cohorts, SPOP RNA expression is significantly associated with the protein abundance of many other proteins, with 16,188 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPOP-associated proteins across cancer lineages are VEZF1, EIF5B_S1168, and PPIF. Each is linked with SPOP in more than 6 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPOP versus VEZF1 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VEZF1 →	+0.424	+0.507	<.001	<.001	3	7
BRCA	EIF5B_S1168 →	-0.550	-0.560	<.001	<.001	3	6
OV	PPIF →	-0.517	-0.484	.004	<.001	2	7
OV	NPEPPS →	+0.403	+0.540	<.001	<.001	3	5
LSCC	CALCOCO2 →	+0.302	+0.304	<.001	.001	3	5
PDAC	CNN3 →	+0.621	+0.254	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,188 associations by consensus.

SPOP vs VEZF1 — BRCA

Explore this scatter interactively →