SPOP

Across TCGA patient cohorts, SPOP protein abundance is significantly associated with the RNA expression of many other genes, with 4,058 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPOP-associated genes across cancer lineages are PLCD4, PROSER2, and MIR767. Each is linked with SPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPOP versus PLCD4 in HNSC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLCD4 →	-1.022	-0.777	.003	<.001	3	2
HNSC	PROSER2 →	+1.009	+0.790	.004	<.001	3	2
HNSC	MIR767 →	+0.803	+0.584	.003	.002	3	2
PDAC	CAMSAP1 →	-0.554	-0.875	.002	.004	3	2
LSCC	CBX2 →	+1.190	+0.291	.001	.004	3	2
LUAD	MEMO1P1 →	+0.575	+0.319	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,058 associations by consensus.

SPOP vs PLCD4 — HNSC

Explore this scatter interactively →