SPOP

Across TCGA patient cohorts, SPOP mutation is significantly associated with the RNA expression of many other genes, with 6,874 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible SPOP-associated genes across cancer lineages are MIR4477A, SNORA10B, and DNAJA1P1. Each is linked with SPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4477A grouped by SPOP-low versus SPOP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4477A →	+0.627	+4.005	.005	.006	3	2
UCS	SNORA10B →	+0.556	+5.087	<.001	.006	3	2
CESC	DNAJA1P1 →	+0.033	+5.306	<.001	.006	3	2
PRAD	CNTNAP3P2 →	-0.127	-2.262	<.001	<.001	3	2
UCEC	HNMT →	-0.482	-1.202	<.001	.001	3	2
PRAD	CARHSP1 →	+0.333	+1.847	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,874 associations by consensus.

MIR4477A by SPOP expression — BRCA

Explore this box plot interactively →