SPOP

Across TCGA patient cohorts, SPOP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible SPOP-associated genes across cancer lineages are EGFR_pY1068, Gab2, and JNK2. Each is linked with SPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SPOP-low versus SPOP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.137	-0.912	.036	.032	3	1
UCEC	Gab2 →	+0.339	+1.514	<.001	.012	3	1
UCEC	JNK2 →	+0.172	+1.469	<.001	<.001	3	1
UCEC	MEK1 →	+0.197	+1.044	.038	.014	3	1
UCEC	Notch1 →	+0.078	+1.453	.032	.012	3	1
UCEC	p21 →	+0.175	+2.083	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR_pY1068 by SPOP expression — UCEC

Explore this box plot interactively →