SPOP

Across TCGA cell cohorts, SPOP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,785 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPOP-associated GO terms across cancer lineages are Heterochromatin formation, Epigenetic regulation of gene expression, and Negative regulation of beige fat cell differentiation. Each is linked with SPOP in more than 15 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by SPOP-low versus SPOP-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Heterochromatin formation →	+0.072	+0.898	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.068	+1.318	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of beige fat cell differentiation →	+0.119	+0.995	<.001	.004	2	16
KIDNEY	Regulation of transcription initiation by RNA polymerase II →	+0.081	+0.684	<.001	.003	3	14
STOMACH	Regulation of nucleotide-excision repair →	+0.085	+0.503	.007	.004	2	15
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.070	+0.998	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,785 associations by consensus.

Heterochromatin formation by SPOP expression — BLOOD_Lymphoma

Explore this box plot interactively →