SPON2

Across TCGA patient cohorts, SPON2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,099 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPON2-associated genes across cancer lineages are POSTN, COL5A1, and ADAMTS12. Each is linked with SPON2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPON2-to-partner and partner-to-SPON2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPON2 versus POSTN in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPON2→partner) and Y-score (partner→SPON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POSTN →	+2.867	+0.842	.001	.006	3	9
GBM	COL5A1 →	+2.249	+1.094	<.001	<.001	3	8
BRCA	ADAMTS12 →	+0.925	+0.453	<.001	<.001	3	8
HNSC	LINC01050 →	+1.348	+0.760	<.001	<.001	3	8
BRCA	NUAK1 →	+0.943	+0.799	<.001	<.001	3	8
GBM	LOX →	+2.062	+1.237	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,099 associations by consensus.

SPON2 vs POSTN — GBM

Explore this scatter interactively →