SPON2

Across TCGA cell cohorts, SPON2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,799 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPON2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Regulation of hydrolase activity, and Actin filament depolymerization. Each is linked with SPON2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPON2-to-partner and partner-to-SPON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by SPON2-low versus SPON2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPON2→partner) and Y-score (partner→SPON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.070	+1.064	<.001	<.001	3	6
SOFT_TISSUE	Regulation of hydrolase activity →	+0.043	+2.467	<.001	.003	3	6
BREAST	Actin filament depolymerization →	+0.081	+1.298	.007	.005	3	6
CNS	Calcium-independent cell-matrix adhesion →	+0.135	+1.577	<.001	<.001	3	6
URINARY_TRACT	Base-excision repair, AP site formation →	+0.068	+1.303	.005	.006	3	5
BLOOD_Leukemia	Lysosome organization →	+0.038	+1.634	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,799 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by SPON2 expression — OVARY

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