Across TCGA patient cohorts, SPOCK3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,538 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPOCK3-associated genes across cancer lineages are PIK3IP1, CRYBB1, and SOX10. Each is linked with SPOCK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK3-to-partner and partner-to-SPOCK3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK3→partner) and Y-score (partner→SPOCK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3IP1 →	+0.835	+0.874	<.001	<.001	3	1
GBM	CRYBB1 →	+0.613	+0.613	.001	<.001	3	1
GBM	SOX10 →	+1.351	+0.872	<.001	<.001	3	1
GBM	TPTEP1 →	+0.952	+0.876	<.001	<.001	3	1
GBM	SUN2 →	+0.628	+1.001	<.001	<.001	3	1
GBM	RASL10A →	+0.995	+0.650	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,538 associations by consensus.

Exploration

SPOCK3 survival (RNA) · tumor vs normal (RNA) · all SPOCK3 data types