SPOCK3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SPOCK3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCK3-associated genes across cancer lineages are GSK-3a-b_pS21_S9, mTOR_pS2448, and ACC_pS79. Each is linked with SPOCK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK3-to-partner and partner-to-SPOCK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK3→partner) and Y-score (partner→SPOCK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADGSK-3a-b_pS21_S9 →-0.374-2.974.028.03532
COADmTOR_pS2448 →-0.174-2.987.024.03532
UCECACC_pS79 →+0.349+1.415.007.04632
SKCMPREX1 →-0.291-1.699.006.00332
UCECSTAT3_pY705 →-0.459-2.169<.001.00332
UCECeIF4E →+0.218+2.169.005.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

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