Across TCGA cell cohorts, SPOCK3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPOCK3-associated genes across cancer lineages are GRK7, OR56A4, and SSX7. Each is linked with SPOCK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK3-to-partner and partner-to-SPOCK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK3→partner) and Y-score (partner→SPOCK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GRK7 →	+0.047	+2.672	.005	.008	3	2
LUNG_NSCLC_LUAD	OR56A4 →	+0.112	+3.040	<.001	.002	3	1
LUNG_NSCLC_LUAD	SSX7 →	+0.011	+3.662	<.001	.001	3	1
LUNG_NSCLC_LUAD	ZNF676 →	+0.921	+2.754	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR8D1 →	+0.031	+2.665	.006	.004	3	1
LUNG_NSCLC_LUAD	OR8B8 →	+0.014	+2.827	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

SPOCK3 survival (RNA) · tumor vs normal (RNA) · all SPOCK3 data types