SPOCK2

Across TCGA pan-cancer cohorts, SPOCK2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPOCK2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPOCK2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPOCK2 expression acts as an unfavorable survival marker.

LUAD, HNSC, and CCRCC are the cancer types where SPOCK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.852	1.000	.007	12	view →
HNSC	OS	Tertile	IV	0.583	0.860	.047	2	view →
CCRCC	DFS	Median	All	0.867	0.972	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPOCK2–LUAD (OS)

Open the LUAD breakdown →