SPOCK2

Across TCGA patient cohorts, SPOCK2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,896 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPOCK2-associated genes across cancer lineages are KLRG1, CD5, and LY9. Each is linked with SPOCK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPOCK2-to-partner and partner-to-SPOCK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPOCK2 versus KLRG1 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK2→partner) and Y-score (partner→SPOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLRG1 →	+0.847	+0.719	<.001	<.001	3	6
HNSC	CD5 →	+1.148	+0.830	<.001	<.001	3	5
HNSC	LY9 →	+1.136	+0.746	<.001	<.001	3	5
HNSC	SP140 →	+1.665	+0.759	<.001	<.001	3	5
GBM	PKMYT1 →	-0.822	-0.493	<.001	.004	3	4
HNSC	PPP1R16B →	+1.704	+0.899	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,896 associations by consensus.

SPOCK2 vs KLRG1 — HNSC

Explore this scatter interactively →