SPOCK2

Across TCGA patient cohorts, SPOCK2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCK2-associated genes across cancer lineages are ERK2, MEK1, and ATM. Each is linked with SPOCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK2-to-partner and partner-to-SPOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SPOCK2-low versus SPOCK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK2→partner) and Y-score (partner→SPOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.169	+2.321	.008	.005	3	2
UCEC	MEK1 →	+0.250	+1.415	.041	.043	3	2
UCEC	ATM →	-0.522	-2.201	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.091	-1.973	.006	.029	3	1
UCEC	GATA6 →	-0.129	-1.807	.017	.025	3	1
UCEC	JNK_pT183_Y185 →	-0.148	-1.415	.008	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ERK2 by SPOCK2 expression — UCEC

Explore this box plot interactively →