SPOCK2

Across TCGA cell cohorts, SPOCK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,954 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPOCK2-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Cytoplasmic translation, and Regulation of myoblast fusion. Each is linked with SPOCK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPOCK2-to-partner and partner-to-SPOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by SPOCK2-low versus SPOCK2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK2→partner) and Y-score (partner→SPOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of mRNA metabolic process →	+0.077	+2.396	<.001	.003	3	8
OVARY	Cytoplasmic translation →	+0.061	+2.701	<.001	<.001	3	8
OVARY	Regulation of myoblast fusion →	+0.078	+2.761	<.001	<.001	3	8
OVARY	Negative regulation of macroautophagy →	+0.064	+2.721	.001	.002	3	7
BREAST	Regulation of purine nucleotide biosynthetic process →	+0.093	+2.513	<.001	.002	3	7
BREAST	Regulation of nucleotide biosynthetic process →	+0.093	+2.513	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,954 associations by consensus.

Negative regulation of mRNA metabolic process by SPOCK2 expression — BREAST

Explore this box plot interactively →