SPOCK2

Across TCGA cell cohorts, SPOCK2 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPOCK2-associated genes across cancer lineages are AZD6094, AZD7969, and GSK2801. Each is linked with SPOCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK2-to-partner and partner-to-SPOCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD6094 grouped by SPOCK2-low versus SPOCK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK2→partner) and Y-score (partner→SPOCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD6094 →	+0.164	+2.871	.048	.021	3	1
LARGE_INTESTINE	AZD7969 →	+0.578	+2.871	.006	.021	3	1
LARGE_INTESTINE	GSK2801 →	+0.390	+2.678	.008	.037	3	1
LARGE_INTESTINE	Eg5_9814 →	+0.647	+2.807	.018	.035	3	1
LARGE_INTESTINE	KIN001-236 →	+0.346	+2.874	.010	.021	3	1
LARGE_INTESTINE	Nilotinib →	+0.448	+2.906	.038	.033	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

AZD6094 by SPOCK2 expression — LARGE_INTESTINE

Explore this box plot interactively →