SPOCD1

Across TCGA patient cohorts, SPOCD1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCD1-associated genes across cancer lineages are Ku80, MEK1, and PDCD4. Each is linked with SPOCD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPOCD1-to-partner and partner-to-SPOCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SPOCD1-low versus SPOCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCD1→partner) and Y-score (partner→SPOCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.215	+1.598	.005	.040	3	3
UCEC	MEK1 →	+0.323	+1.938	.007	.001	3	2
UCEC	PDCD4 →	-0.326	-1.575	.035	.034	3	2
UCEC	ATM →	-0.488	-1.938	.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.559	+1.604	.004	.021	3	2
UCEC	C-Raf →	+0.123	+1.584	.009	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Ku80 by SPOCD1 expression — UCEC

Explore this box plot interactively →