SPOCD1

Across TCGA cell cohorts, SPOCD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,650 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPOCD1-associated GO terms across cancer lineages are Transposable element silencing by piRNA-mediated heterochromatin formation, Regulation of proteolysis, and Positive regulation of angiogenesis. Each is linked with SPOCD1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPOCD1-to-partner and partner-to-SPOCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transposable element silencing by piRNA-mediated heterochromatin formation grouped by SPOCD1-low versus SPOCD1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCD1→partner) and Y-score (partner→SPOCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Transposable element silencing by piRNA-mediated heterochromatin formation →	+2.062	+3.743	<.001	<.001	3	17
BONE	Regulation of proteolysis →	+0.120	+3.188	<.001	<.001	3	16
BONE	Positive regulation of angiogenesis →	+0.121	+4.147	<.001	<.001	3	14
LIVER	Regulation of protein processing →	+0.181	+3.976	<.001	<.001	3	14
BONE	Integrin-mediated signaling pathway →	+0.270	+3.598	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.165	+3.420	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,650 associations by consensus.

Transposable element silencing by piRNA-mediated heterochromatin formation by SPOCD1 expression — LIVER

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