SPOCD1

Across TCGA cell cohorts, SPOCD1 mutation is significantly associated with the RNA expression of many other genes, with 405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPOCD1-associated genes across cancer lineages are IL36A, NR2C1, and NEDD1. Each is linked with SPOCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCD1-to-partner and partner-to-SPOCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by SPOCD1-low versus SPOCD1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCD1→partner) and Y-score (partner→SPOCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	2
LARGE_INTESTINE	NR2C1 →	+0.625	+3.299	<.001	.004	3	2
LARGE_INTESTINE	NEDD1 →	+0.738	+3.212	<.001	.006	3	2
LARGE_INTESTINE	FBXO25 →	+0.905	+3.212	.002	.006	3	2
LARGE_INTESTINE	THAP9 →	+0.686	+3.212	<.001	.006	3	2
LARGE_INTESTINE	MCUB →	+0.877	+3.212	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

IL36A by SPOCD1 expression — LUNG_SCLC

Explore this box plot interactively →