SPNS2

Across TCGA patient cohorts, SPNS2 protein abundance is significantly associated with the RNA expression of many other genes, with 901 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SPNS2-associated genes across cancer lineages are EMCN, DES, and MIOX. Each is linked with SPNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS2-to-partner and partner-to-SPNS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPNS2 versus EMCN in LUAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS2→partner) and Y-score (partner→SPNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EMCN →	+0.513	+0.673	<.001	<.001	3	2
LUAD	DES →	+1.492	+0.973	<.001	<.001	3	2
LUAD	MIOX →	-0.739	-0.577	.003	.002	3	1
LUAD	SNW1 →	+0.290	+0.648	<.001	<.001	3	1
LUAD	SRSF5 →	+0.325	+0.632	.002	.007	3	1
LUAD	EIF5 →	+0.256	+0.637	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 901 associations by consensus.

SPNS2 vs EMCN — LUAD

Explore this scatter interactively →