SPNS2

Across TCGA cell cohorts, SPNS2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPNS2-associated genes across cancer lineages are AMELX, KRTAP17-1, and PNMA6F. Each is linked with SPNS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS2-to-partner and partner-to-SPNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMELX grouped by SPNS2-low versus SPNS2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS2→partner) and Y-score (partner→SPNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AMELX →	+0.031	+4.977	<.001	.007	3	1
SKIN	KRTAP17-1 →	+0.025	+4.977	<.001	.007	3	1
SKIN	PNMA6F →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	GPR101 →	+0.085	+3.551	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	MOGAT1 →	+0.091	+2.878	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

AMELX by SPNS2 expression — SKIN

Explore this box plot interactively →