SPNS1

Across TCGA pan-cancer cohorts, SPNS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPNS1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SPNS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPNS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where SPNS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.836	.011	20	view →
HNSC	OS	Tertile	IV	0.727	0.976	.016	14	view →
UCEC	DFS	Tertile	All	0.781	0.970	.011	8	view →
PDAC	DFS	Tertile	All	0.679	0.855	.020	7	view →
LUAD	OS	Tertile	II,III,IV	0.915	0.556	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPNS1–CCRCC (DFS)

Open the CCRCC breakdown →