SPNS1

Across TCGA patient cohorts, SPNS1 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPNS1-associated genes across cancer lineages are RPS29P15, OR2B7P, and OR2B3. Each is linked with SPNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS1-to-partner and partner-to-SPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P15 grouped by SPNS1-low versus SPNS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS1→partner) and Y-score (partner→SPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS29P15 →	+0.234	+3.047	.001	.004	3	2
HNSC	OR2B7P →	+0.050	+5.069	.004	.008	3	2
HNSC	OR2B3 →	+0.048	+5.505	<.001	.004	3	2
UCEC	BAG3 →	+0.538	+2.662	.003	<.001	3	2
UCEC	PKN3 →	+0.645	+3.584	<.001	.002	3	2
UCEC	CCDC116 →	+0.221	+2.732	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

RPS29P15 by SPNS1 expression — SKCM

Explore this box plot interactively →