SPNS1

Across TCGA patient cohorts, SPNS1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPNS1-associated genes across cancer lineages are p90 RSK, ATM, and Fibronectin. Each is linked with SPNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS1-to-partner and partner-to-SPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by SPNS1-low versus SPNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS1→partner) and Y-score (partner→SPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.254	+2.469	.001	.010	3	2
UCEC	ATM →	-0.477	-2.222	.013	.011	3	2
UCEC	Fibronectin →	-0.290	-2.312	.038	.034	3	1
UCEC	HSP70 →	-0.416	-3.321	.014	.009	3	1
UCEC	IGFBP2 →	-0.938	-2.222	<.001	.011	3	1
UCEC	JNK2 →	+0.200	+2.834	.017	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p90 RSK by SPNS1 expression — UCEC

Explore this box plot interactively →