SPNS1

Across TCGA cell cohorts, SPNS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,056 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPNS1-associated GO terms across cancer lineages are Lysosome organization, Lytic vacuole organization, and Multi-pass transmembrane protein insertion into ER membrane. Each is linked with SPNS1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPNS1-to-partner and partner-to-SPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosome organization grouped by SPNS1-low versus SPNS1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS1→partner) and Y-score (partner→SPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Lysosome organization →	+0.085	+0.906	<.001	<.001	3	15
SKIN	Lytic vacuole organization →	+0.085	+0.906	<.001	<.001	3	15
LUNG_SCLC	Multi-pass transmembrane protein insertion into ER membrane →	+0.127	+0.636	<.001	<.001	3	15
BLOOD_Myeloma	Lysosomal lumen acidification →	+0.105	+0.985	.004	<.001	3	15
STOMACH	Vacuolar acidification →	+0.124	+0.954	.003	<.001	3	13
BREAST	Negative regulation of autophagosome maturation →	+0.085	+0.741	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,056 associations by consensus.

Lysosome organization by SPNS1 expression — SKIN

Explore this box plot interactively →